Anti-Human IL-12 Rβ1

Product No.: I-745


Target IL-12 R beta 1 Product Type Polyclonal Antibody Alternate Names Interleukin-12 Receptor Beta 1, IL12RB1, CD212, IL-12R-BETA1, IL12RB, MGC34454 Applications WB


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Antibody Details Product Details Reactive Species Human Host Species Goat Immunogen NS0-Derived Recombinant Human Interleukin-12 Receptor β1 Extracellular Domain Endotoxin Level <0.1 EU/µg as determined by the LAL method Formulation This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present. State of Matter Lyophilized Storage and Handling The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months. Country of Origin USA Shipping Next Day Ambient RRIDAB_2830866 Applications and Recommended Usage? Quality Tested by Leinco Western Blotting: To detect Human IL-12 Rβ1 this polyclonal antibody can be used at a concentration of 0.1 - 0.2 µg/ml. This polyclonal antibody should be used in conjunction with compatible second-step reagents such as PN:G505 and a chromogenic substrate such as PN:T343. The detection limit for Human IL-12 Rβ1 is 20 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Goat Anti-Human Interleukin 12 Receptor Beta 1 (IL-12 Rβ1) recognizes Human IL-12 Rβ1. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research. Background Interleukin 12 receptor, beta 1 (IL12RB1) also known as CD212 (cluster of differentiation 212) is a subunit of the interleukin 12 receptor. IL12RB1 is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. IL-12 Rβ1 defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species.¹ PubMed IL-12 R beta 1 NCBI Gene Bank ID 3594 UniProt.org More Information on Uniprot.org References & Citations 1. Ersoy, F. et al. (2007) Pediatr. Infect. Dis. J. 26: 366 View product citations for antibody PRODUCT_CODE on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Human

Host Species

Goat

Immunogen

NS0-Derived Recombinant Human Interleukin-12 Receptor β1 Extracellular Domain

Endotoxin Level

<0.1 EU/µg as determined by the LAL method

Formulation

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

State of Matter

Lyophilized

Storage and Handling

The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.

Country of Origin

USA

Shipping

Next Day Ambient

RRIDAB_2830866

Applications and Recommended Usage?
Quality Tested by Leinco

Western Blotting: To detect Human IL-12 Rβ1 this polyclonal antibody can be used at a concentration of 0.1 - 0.2 µg/ml. This polyclonal antibody should be used in conjunction with compatible second-step reagents such as PN:G505 and a chromogenic substrate such as PN:T343. The detection limit for Human IL-12 Rβ1 is 20 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Goat Anti-Human Interleukin 12 Receptor Beta 1 (IL-12 Rβ1) recognizes Human IL-12 Rβ1. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

Background

Interleukin 12 receptor, beta 1 (IL12RB1) also known as CD212 (cluster of differentiation 212) is a subunit of the interleukin 12 receptor. IL12RB1 is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. IL-12 Rβ1 defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species.¹

PubMed

IL-12 R beta 1

NCBI Gene Bank ID

3594

UniProt.org

More Information on Uniprot.org