This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Applications and Recommended Usage ?
(Quality Tested by Leinco)
Western Blotting: IL-21 antibody can be used for detection of IL-21 by Western blot at 1 μg/mL.
Rabbit Anti-Human Interleukin-21 (IL-21) recognizes an epitope in the intermediate domain of Human IL-21. This polyclonal antibody was purified using affinity chromatography.
Interleukin 21 (IL-21) is a T cell-derived pleiotropic cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.1,2 This cytokine induces cell division/proliferation in its target cells. IL-21 elicits its effects on immune cells by interacting with a cell surface receptor known as the interleukin 21 receptor, IL-21R, which is expressed in bone marrow cells and various lymphocytes. IL-21 is closely related to IL-2 and IL-153 and is a key factor in the transition between innate and adaptive immune responses.4 The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.5
NCBI Gene Bank ID
References & Citations
1. Foster D et al. (2000) Nature 408: 57 2. Clegg CH et al. (2002) J. Leukoc. Biol. 72: 856 3. Leonard WJ.et al. (2002) Science 298: 1630 4. Joannopoulos K.et al. (2003) J. Immunol. 171: 608 5. Lipsky PE. et al. (2008) Ann Rheum. Dis. 3: 83
Products are for research use only. Not for use in diagnostic or therapeutic procedures.