Anti-Human IL-22R (CT)
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen PN:I-361 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2830650 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Anti-Human Interleukin-22 Receptor (IL-22R) recognizes an epitope near the C-terminus of Human and Rat IL-22R. This polyclonal antibody was purified using affinity chromatography. Background A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified.1-3 The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family.3,4 IL-22R forms a complex with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-a 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response. PubMed NCBI Gene Bank ID UniProt.org References & Citations1. Dumoutier, L. et al. (2000) J. Immunol. 164(4):1814
2. Dumoutier, L. et al. (2000) Proc. Natl. Acad. Sci. USA 97(18):10144
3. Xie, M. H. et al. (2000) J. Biol. Chem. 275(40):31335
4. Kotenko, S. V. et al. (2001) J. Biol. Chem. 276(4):2725 Technical ProtocolsCertificate of Analysis |
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I-358 | |
I-360 | |
I-359 | |
I-361 |
