Anti-Human IL-22R (NT)

PN:I-359

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Interleukin-22 Receptor (IL-22R) recognizes an epitope near the N-terminus of Human and Rat IL-22R. This polyclonal antibody was purified using affinity chromatography.

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified.^1-3 The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family.^3,4 IL-22R forms a complex with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-a 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.

1. Dumoutier, L. et al. (2000) J. Immunol. 164(4):1814 2. Dumoutier, L. et al. (2000) Proc. Natl. Acad. Sci. USA 97(18):10144 3. Xie, M. H. et al. (2000) J. Biol. Chem. 275(40):31335 4. Kotenko, S. V. et al. (2001) J. Biol. Chem. 276(4):2725