Anti-Human IRAK
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen PN:I-321 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2830628 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Anti-Human IL-1 Receptor-Associated Kinase (IRAK) recognizes Human, Mouse and Rat IRAK. This polyclonal antibody was purified using affinity chromatography. Background Nuclear factor κ B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF). PubMed References & Citations1. Cao, Z. et al. (1996) Science 271:1128 2. Trofimova, M. et al. (1996) J. Bio. Chem. 271:17609 3. Jianing, H. et al. (1997) Proc. Natl. Acad. Sci. USA 94:12829 4. Robinson, D. et al. (1997) Immunity 7:571 Technical ProtocolsCertificate of Analysis |
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