Anti-Human IRF3 (CT)
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen PN:I-518 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2830717 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Anti-Human Interferon Regulatory Factor-3 (IRF3) recognizes an epitope near the C-terminus of Human and Mouse IRF3. This polyclonal antibody was purified using affinity chromatography. Background Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-α/β genes. IRF3 is present in an inactive form in the cytoplasm of most cells.2 Following viral infection, IRF3 can be activated by IκB kinase-ε and TANK-binding kinase 1 (TBK1),3,4 whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA.3 IRF3 exists as at least two distinct isoforms. PubMed NCBI Gene Bank ID UniProt.org References & Citations1. Malmgaard, L. (2004) J. Interferon & Cyto. Res. 24:439
2. Au, W. C. et al. (1995) Proc. Natl. Acad. Sci. USA 92:11657
3. Fitzgerald, K. A. et al. (2003) Nat. Immunol. 4:491
4. Sharma, S. et al. (2003) Science 300:1148 Technical ProtocolsCertificate of Analysis |
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