Anti-Human Kelch-Like 1 Protein (KLHL1)

Anti-Human Kelch-Like 1 Protein (KLHL1)

Product No.: K129

[product_table name="All Top" skus="K129"]

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Target
Kelch-Like 1 Protein
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB

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Select Product Size
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:K130
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Kelch-Like 1 Protein (KLHL1) recognizes an epitope near the N'terminus of human and rat KLHL1. This polyclonal antibody was purified using affinity chromatography.
Background
The mammalian Kelch-like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues.1,2 The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin-organizing proteins.3 Based on the presence of anti-sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.1

Antigen Details

NCBI Gene Bank ID

References & Citations

1. Nemes, J. P. et al. (2000) Human Mol. Gen. 9:1543 2. Adams, J. et al. (2000) Trends Cell Biol. 10:17 3. Robinson, D. N. et al. (1997) J. Cell Biol. 138:799
IHC FFPE
General Western Blot Protocol

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.