Anti-Human MMP-13 (Clone M31.387)

Pricing & Details

Product No.M1088
Clone
M31.387
Protein
MMP-13
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Collagenase 3, CLG3, CL3
Isotype
Mouse
IgG1
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
M1088-0.2 mg
0.2 mg
$252.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Immunogen
a synthetic peptide corresponding to amino acids 131 to 140 of human MMP-13
Product Concentration
0.1 mg/ml
Formulation
This purified antibody is formulated with no carrier proteins or preservatives added in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl.
Storage and Handling
This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Anti-Human MMP-13 (clone M31.387) was produced in mice using a synthetic peptide corresponding to amino acids 131 to 140 of human MMP-13. This antibody recognizes the approximately 54-60 kDa latent human MMP-13.
Background
Matrix metallopeptidase 13 (collagenase 3), also known as MMP13, is a glycosylated protein1 and a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, which is expressed in the skeleton during embryonic development2 and are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. MMP-13 is tightly bound to tissues and utilizes heparan sulfate proteoglycans as extracellular docking molecules. It is produced by many different cell types as an inactive proform that requires proteolytic activation to gain activity.3 Mutations causing lack of MMP-13 expression have been shown to be associated with skeletal disorders characterized by defective growth and modeling of the spine and long bones (spondyloepimetaphyseal dysplasias).4

Antigen Details

Protein
PubMed
Research Area
Apoptosis
.
Cell Biology
.
Immunology

References & Citations

1. Knäuper, V. et al. (1996) J Biol. Chem. 271: 17124
2. Krane, SM. et al. (2004) Proc Natl Acad Sci U S A. 101(49):17192-7
3. Woessner, JF. et al. (2000) J Biol. Chem. 275: 4183
4. Kennedy, AM. et al. (2005) J Clin. Invest. 115: 2832
General Western Blot Protocol

Formats Available

Prod No.
Description
M1088
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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