Anti-Human Ribosomal Protein S6 Kinase 1 (RPS6K1)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human Ribosomal Protein S6 Kinase 1 (RPS6K1)

Pricing & Details

Product No.R1235
Protein
RPS6K1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
S6K, p70 S6 Kinase, p70-S6K
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
R1235-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
R1235-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:R1240
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Ribosomal Protein S6 Kinase 1 (RPS6K1) recognizes Human RPS6K1. This polyclonal antibody was purified using affinity chromatography.
Background
Ribosomal protein S6 kinase 1 (RPS6K1) is the best characterized effector of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors/1,2 Nutrients and growth factors stimulate a complex including TOR, raptor (regulatory associated protein of TOR), and GBL to phosphorylate RPS6K1 and the eukaryotic initiation factor 4E binding protein (4EBP1), leading to increased protein synthesis and cell growth.3 RPS6K1 is thought to desensitize tissues to insulin as mice deficient in RPS6K1 have been shown to be hypersensitive to insulin and impervious to obesity-induced insulin resistance seen in wild type obese mice.4

Antigen Details

Protein
PubMed

References & Citations

1. Burnett, PE. et al. (1998) Proc. Natl. Acad. Sci. USA 95:1432
2. Inoki, K. et al. (2005) Mol. Biol. Rev. 69:79
3. Manning, BD. (2004) J. Cell Biol. 167:399
4. Um, SH. et al. (2004) Nature 431:200
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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