Anti-Human TCR Vα24-Jα18 (iNKT cell)- PE

Anti-Human TCR Vα24-Jα18 (iNKT cell)- PE

Product No.: T1707

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TCR Vα24-Jα18
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
TCR Vα24-Jα18, TCR Vα24-JαQ, invariant NKT cell, iNKT
IgG1 κ

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Antibody Details

Product Details

Reactive Species
Host Species
Product Concentration
0.2 mg/ml
This R-phycoerythrin (R-PE) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This R-phycoerythrin (R-PE) conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
Next Day 2-8°C
Excitation Laser
Blue Laser (488 nm) and/or Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Applications and Recommended Usage?
Quality Tested by Leinco
FC The suggested concentration for this TCR Vα24-Jα18 antibody for staining cells in flow cytometry is ≤ 5.0 μg per 106 cells in a volume of 100 μl or 100μl of whole blood. Titration of the reagent is recommended for optimal performance for each application.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.


Clone 6B11 recognizes the invariant CDR3 region of the human Vα24-Jα18 TCR.
TCR Vα24-Jα18 antibody, 6B11, recognizes the CDR3 region of the V alpha 24 and J alpha 18 TCR alpha locus (Vα24-Jα18). The Vα24-Jα18 semi-invariant TCR is expressed on a highly conserved T cell subset, named invariant natural killer T (iNKT cells), which also express NK cell-associated molecules. The Vα24-Jα18 TCR recognizes lipid antigens, such as α-galactosylceramide (α-GalCer), presented by the MHC class I-like molecule CD1d1. Following activation, iNKT cells rapidly proliferate and produce large amounts of IL-4, IFNγ, and cytolytic mediators2,3. iNKT cells have both inflammatory and immunoregulatory functions and are implicated in anti-tumor immunity, protection against infections, suppression of autoimmunity, and the development of inflammatory diseases4.
Antigen Distribution
The Vα24-Jα18 TCR is expressed on iNKT cells.

Antigen Details

Glycolipid loaded CD1d
NCBI Gene Bank ID
Research Area

References & Citations

1. Van Kaer L., et al. (2004) Nat Rev Immunol. 4(3):231-7
2. Teyton L., et al. (2006) Annu Rev Immunol. 25:297–336
3. Kronenberg M. (2004) Annu Rev Immunol. 23:877–900
4. Van Kaer L & Wu L. (2018) Front Immunol. 9:519
Flow Cytometry

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.