This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human TIM-4 recognizes an epitope near the C-terminus of Human, Mouse and Rat TIM-4. This polyclonal antibody was purified using affinity chromatography.
The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.
References & Citations
1. Meyers, JH. et al. (2005) Trends Mol. Med. 11:362
2. Meyers, JH. et al. (2005) Nat. Immunol. 6:455
3. Kuchroo, VK. et al. (2003) Nat. Rev. Immunol. 3:454-62
4. Shakhov, AN. et al. (2004) Eur J Immunol. 34(2):494-503.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.