Anti-Human X Box Binding Protein 1 (CT) (XBP-1)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human X Box Binding Protein 1 (CT) (XBP-1)

Pricing & Details

Product No.X100
Protein
X Box Binding Protein 1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Tax-Responsive Element Binding Protein 5
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
X100-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
X100-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:X109
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human X Box Binding Protein 1 (XBP-1) recognizes an epitope near the C-terminus of Human, Mouse and Rat XBP-1. This polyclonal antibody was purified using affinity chromatography.
Background
X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.3,4

Antigen Details

References & Citations

1. Yoshida, H. et al. (2001) Cell 107:881
2. Calfon, M. et al. (2002) Nature 415:92
3. Haze, K. et al. (1999) Mol. Cell. Biol. 10:3787
4. Little, E. et al. (1994) Crit. Rev. Eukaryot. Gene Expr. 4:1
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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