Anti-Human XAF-1 (CT)

Pricing & Details

Product No.X103
Protein
XAF-1
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
X103-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
X103-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:X108
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human XAF-1 recognizes an epitope near the C-terminus of Human and Mouse XAF-1. This polyclonal antibody was purified using affinity chromatography.
Background
XAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus.1,2 Overexpression of XAF-1 results in the neutralization of XIAP's ability to inhibit cell death.1 XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines.3 In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF-1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines.2,3 Both IFN-α2 and IFN-β can induce XAF-1 mRNA in all cells examined but induction of XAF-1 protein (as observed by immunoblot analysis) was seen only in cell lines sensitive to the apoptotic effects of IFNs.4

Antigen Details

Protein
PubMed

References & Citations

1. Liston, P. et al. (2001) Nature Cell Biol. 3:128
2. Deveraux, QL. et al. (1997) Nature 388:300
3. Fong, WG. et al. (2000) Genomics 70:113
4. Leaman, DW. et al. (2002) J. Biol. Chem. 277:28504
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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