Anti-Human ZIPK (Intermediate Domain)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human ZIPK (Intermediate Domain)

Pricing & Details

Product No.Z100
Protein
ZIPK
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
ZIP kinase
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
Z100-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
Z100-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:Z101
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human ZIPK recognizes an epitope in the intermediate domain of Human, Mouse and Rat ZIPK. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N-terminal kinase domain and a C-terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREB family. ZIP kinase has high sequence homology to DAP kinase (death-associated protein kinase), which is a mediator of apoptosis induced by γ interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues.

Antigen Details

Protein
PubMed

References & Citations

1. Kawai, T. et al. (1998) Mol. Cell Biol. 18:1642
IHC
General Western Blot Protocol
Prod No.
Description
Z100
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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