Anti-Mouse CD71 – FITC

Anti-Mouse CD71 – FITC

Product No.: C277

[product_table name="All Top" skus="C277"]

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Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Transferrin Receptor

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Antibody Details

Product Details

Reactive Species
Host Species
Product Concentration
0.5 mg/ml
This Fluorescein (FITC) antibody conjugate is formulated in 0.01 M phosphate-buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Product Preparation
The monoclonal antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Storage and Handling
This Fluorescein conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
Next Day Ambient
Excitation Laser
Blue Laser (488 nm)
Applications and Recommended Usage?
Quality Tested by Leinco
FC The suggested concentration for this R17217 antibody for staining cells in flow cytometry is ≤ 0.1 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application.
Additional Reported Applications For Relevant Conjugates ?
For specific conjugates of this clone, review literature for suggested application details.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.


Clone R17217 recognizes an epitope on CD71.
Antigen Distribution
CD71 is expressed on most proliferating cells, activated lymphocytes, monocytes, macrophages, erythroid progenitors, and brain endothelium.
CD71 is a 95 kD type II homodimeric transmembrane glycoprotein. The function of CD71 is believed to be primarily nutritional. It plays a role in the control of cellular proliferation through facilitation of iron uptake by way of ferrotransferrin binding and the recycling of apotransferrin to the cell surface. Additionally, transferrin receptor is required for erythropoiesis and proper neurological development, and it has also been suggested that a growth signal might be generated by the transferrin/transferrin receptor interaction. Current genetic analysis indicates that the structural genes for transferrin receptor and for a melanoma-associated antigen (p97), and perhaps transferrin itself, each map to a common chromosome in humans. These proteins exhibit primary sequence homology with transferrin and have the ability to bind ferric iron. Therefore, it is thought that genetic rearrangements in this iron transport region may be associated with malignant transformation. Hence, anti-CD71 mAbs are thought to have therapeutic potential in cases of human leukemia & lymphoma.

Antigen Details

Mediates iron uptake.
NCBI Gene Bank ID

References & Citations

1. Lesley, J. et al. (1982) Immunogenetics 15:313
2. Lesley, J. et al. (1984) Mol. Cell. Biol. 4(9):1675
3. Kemp, JD. et al. (1987) J. Immunol. 138:2422
4. Kemp, JD. et al. (1989) Cell Immunol. 122:218
Flow Cytometry
Products are for research use only. Not for use in diagnostic or therapeutic procedures.