Anti-Human CD71 (Transferrin Receptor) – PerCP

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Pricing & Details

Product No.C2006
Clone
T56/14
Protein
CD71
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Transferrin Receptor
Isotype
Mouse
IgG1
Applications
FC
Prod No.
Size
Price
Avail.
Qty
Add to cart
C2006-Custom
Custom
In stock
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Immunogen
Purified Recombinant Human CD71 (>98%)
Product Concentration
0.1 mg/ml
Formulation
This PerCP conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This PerCP conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone T56/14 recognizes human CD71.
Antigen Distribution
CD71 is expressed on most proliferating cells, activated lymphocytes, monocytes, macrophages, erythroid progenitors, and brain endothelium.
Background
CD71 is a 95 kD type II homodimeric transmembrane glycoprotein. The function of CD71 is believed to be primarily nutritional. It plays a role in the control of cellular proliferation through facilitation of iron uptake by way of ferrotransferrin binding and the recycling of apotransferrin to the cell surface. Additionally, transferrin receptor is required for erythropoiesis and proper neurological development, and it has also been suggested that a growth signal might be generated by the transferrin/transferrin receptor interaction. Current genetic analysis indicates that the structural genes for transferrin receptor and for a melanoma-associated antigen (p97), and perhaps transferrin itself, each map to a common chromosome in humans. These proteins exhibit primary sequence homology with transferrin and have the ability to bind ferric iron. Therefore, it is thought that genetic rearrangements in this iron transport region may be associated with malignant transformation. Hence, anti-CD71 mAbs are thought to have therapeutic potential in cases of human leukemia & lymphoma.

Antigen Details

Protein
Ligand/Receptor
Transferrin
PubMed
NCBI Gene Bank ID
Research Area
Immunology

References & Citations

1. Trowbridge, SI. et al. (1981) Proc. Nat'l. Acad. Sci. 78:3039
2. Iacopetta, BJ. et al. (1983) J. Histochem. Cytochem. 31:336
Flow Cytometry

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.