Anti-Mouse CD8a (Ly 2.2) – Biotin
Anti-Mouse CD8a (Ly 2.2) – Biotin
Product No.: C298
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Clone 2.43 Target CD8a Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Ly 2.2 Isotype IgG2b Applications FC , IP |
Data
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Product Concentration 0.5 mg/ml Formulation This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This biotinylated antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day Ambient RRIDAB_2829626 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone 2.43 recognizes an epitope on mouse CD8a. Background CD8 is made up of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8 is part of the Ig superfamily that expresses primarily as CD8a homodimers. CD8a is a 32-34 kD type I glycoprotein that can also form heterodimers with CD8b. CD8 is an antigen co-receptor on T cells that mediates efficient cell to cell interactions within the immune system. CD8 coupled with the T cell receptor on the T lymphocyte recognizes an antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The CD8 co-receptor also plays a role in T cell signaling by interacting with Lck (lymphocyte-specific protein tyrosine kinase) which leads to the activation of transcription factors that affect the expression of certain genes. Antigen Distribution CD8a is present on the surface of most thymocytes and a subpopulation of mature T-lymphocytes which include most T suppressor/cytotoxic-cells. Ligand/Receptor MHC class I molecule PubMed NCBI Gene Bank ID UniProt.org References & Citations1. Sarmiento, M. et al. (1980) J. of Immunol. 125:2665
2. Fitch, F. W. et al. (1982) Immunol. Rev. 68:135
Technical ProtocolsCertificate of Analysis |
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