Anti-Mouse GFRα-3 (Intermediate Domain)
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rabbit Immunogen Purified Recombinant Mouse GFRα-3 (>98%) Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2830237 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Anti-Mouse GFRα-3 recognizes a epitope in the intermediate domain human, mouse and rat GFRα-3. This polyclonal antibody was purified using affinity chromatography. Background GDNF family receptor alpha 3, also known as GFRA3 is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. GFRalpha3 preferentially binds the newest member of the glial-derived neurotrophic factor family of ligands, artemin. The major site of GFRalpha3 expression is in the dorsal root ganglion. GFRalpha3 artemin neurons are immunopositive for markers expected of nociceptors and include a subset of neurons distinct from the GDNF-responsive population.1glycosylphosphadidylinositol linked protein GFRα and Ret receptor tyrosine kinase GFRβ (2). Following the findings of GFRα-1 and -2, a novel receptor in GFRα family was identified very recently from human and mouse and designated GFRα-3 (3-7). GFRα-3 binds persephin, thus, persephin, GFRα-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function. Antigen DetailsNCBI Gene Bank ID UniProt.org References & Citations1. Sanicola M. et al. (2001)Eur J Neurosci 13: 2177 Technical Protocols |
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