Anti-Mouse GFRα-3 (Intermediate Domain)

Anti-Mouse GFRα-3 (Intermediate Domain)

Product No.: G578

[product_table name="All Top" skus="G578"]

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Target
Glial Cell Line-Derived Neurotropic Factor Receptor Alpha 3
Product Type
Polyclonal Antibody
Alternate Names
GDNFRγ, GDNFRgamma
Applications
IHC FFPE
,
WB

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Product Size
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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Rabbit
Immunogen
Purified Recombinant Mouse GFRα-3 (>98%)
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Mouse GFRα-3 recognizes a epitope in the intermediate domain human, mouse and rat GFRα-3. This polyclonal antibody was purified using affinity chromatography.
Background
GDNF family receptor alpha 3, also known as GFRA3 is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. GFRalpha3 preferentially binds the newest member of the glial-derived neurotrophic factor family of ligands, artemin. The major site of GFRalpha3 expression is in the dorsal root ganglion.

GFRalpha3 artemin neurons are immunopositive for markers expected of nociceptors and include a subset of neurons distinct from the GDNF-responsive population.1glycosylphosphadidylinositol linked protein GFRα and Ret receptor tyrosine kinase GFRβ (2). Following the findings of GFRα-1 and -2, a novel receptor in GFRα family was identified very recently from human and mouse and designated GFRα-3 (3-7). GFRα-3 binds persephin, thus, persephin, GFRα-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

Antigen Details

NCBI Gene Bank ID

References & Citations

1. Sanicola M. et al. (2001)Eur J Neurosci 13: 2177
IHC FFPE
General Western Blot Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.