Anti-Mouse NK1.1 – DyLight® 755

Anti-Mouse NK1.1 – DyLight® 755

Product No.: N226

[product_table name="All Top" skus="N226"]

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Clone
PK136
Target
NK1.1
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Natural Killer Cells, KR-P1C, NKR-P1B, Ly-55, CD161b, CD161c
Isotype
IgG2a
Applications
FC

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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Mouse
Immunogen
Purified Recombinant Mouse Natural Killer Cells (>98%)
Product Concentration
0.5 mg/ml
Formulation
This DyLight<sup>®</sup> 755 conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This DyLight® 755 conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone PK136 recognizes mouse NK1.1.
Background
NK1.1 is a type II membrane protein that is part of the C-type lectin superfamily. NK1.1 contains a transmembrane domain and a cytoplasmic domain that are characteristic of C-type lectins. The function of NK cells is to mediate cytotoxicity and to secrete cytokines after immune stimulation. NK1.1 has been correlated with lysis of tumor cells In vitro and rejection of bone marrow allografts In vivo. It is also involved in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 is commonly used as a mouse NK cell marker.
Antigen Distribution
NK-1.1 is encoded by the NKR-P1B/NKR-P1C gene and expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129.

Antigen Details

PubMed
NCBI Gene Bank ID
Research Area
Immunology
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Innate Immunity

References & Citations

1. Koo, G. C. and Peppard, J. R. (1986) Hybridoma 3:301
Flow Cytometry

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.