Anti-Mouse/Rat CD71 – Purified

PHA-activated rat lymph node cells

This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Next Day 2-8°C

Clone OX-26 reacts with rat CD71 (TfR1).

CD71 is a transferrin receptor on the cell surface that mediates the uptake of transferrin-iron complexes, thereby mediating cellular proliferation¹. CD71 is a homodimeric glycoprotein containing 760 amino acids and it binds to diferric transferrin². Binding by diferric transfferin causes CD71 to be internalized, and diferric iron is subsequently released³. CD71 is highly expressed on malignant cells, as iron uptake is necessary for aberrant cell proliferation⁴.

CD71 is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors.

Transferrin

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4. Candelaria PV, Leoh LS, Penichet ML, Daniels-Wells TR. Front Immunol. Mar 17;12:607692. 2021
5. Jiménez E, Sacedón R, Vicente A, et. al. J Immunol. May 15;168(10):5005-13. 2002.
6. Fabriek BO, Polfliet MM, Vloet RP, et. al. Blood. Jun 15;109(12):5223-9. 2007.