Antibody DetailsProduct DetailsReactivity Species Mouse Host Species Armenian Hamster Product Concentration 0.5 mg/ml Formulation This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This biotinylated antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day Ambient RRIDAB_2831865 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Clone 55R-170 recognizes mouse CD120a. Antigen Distribution CD120a is constitutively expressed in most tissues. Background Tumor Necrosis Factor Receptor Type I (TNFRI) is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-α and TNF-ß (also known as LT-α). The subsequent signaling is known to be important for inducing cytolytic activity, antiviral activity, expression of manganous superoxide dismutase and intercellular adhesion molecule (ICAM), IL-6 mRNA accumulation and NF-ĸB induction. TNFRI carries an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein).
Binding of 55R-170 antibody to TNFRI has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding.
Antigen DetailsProtein PubMed Research Area Immunology . Innate Immunity References & Citations1. Dana, R. et al. (2000) Arch Ophthalmol. 118: 1666 2. Donner, DB. et al. (2008) J Immunol. 181: 1288 3. Pasparakis, M. et al. (2008) Nat Immunol. 9: 1015 Technical Protocols |
Formats Available
Prod No. | Description |
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T583 |
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T249 |
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T575 |
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T576 |
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T577 |
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T579 |
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T581 |
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T248 |
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T250 |
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T950 |
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T440 |
