Anti-Mouse CD120a (TNFR1) (Clone 55R-170) – Purified

Anti-Mouse CD120a (TNFR1) (Clone 55R-170) – Purified

Product No.: T248

[product_table name="All Top" skus="T248"]

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Clone
55R-170
Target
TNFR1
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
CD120α, TNFRSF1A, P55, P60
Isotype
IgG
Applications
FC
,
IP

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Product Size
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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Armenian Hamster
Product Concentration
0.5 mg/ml
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone 55R-170 recognizes mouse CD120a.
Antigen Distribution
CD120a is constitutively expressed in most tissues.
Background
Tumor Necrosis Factor Receptor Type I (TNFRI) is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-α and TNF-ß (also known as LT-α). The subsequent signaling is known to be important for inducing cytolytic activity, antiviral activity, expression of manganous superoxide dismutase and intercellular adhesion molecule (ICAM), IL-6 mRNA accumulation and NF-ĸB induction. TNFRI carries an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein). Binding of 55R-170 antibody to TNFRI has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding.

Antigen Details

Research Area
Immunology
.
Innate Immunity

References & Citations

1. Dana, R. et al. (2000) Arch Ophthalmol. 118: 1666
2. Donner, DB. et al. (2008) J Immunol. 181: 1288
3. Pasparakis, M. et al. (2008) Nat Immunol. 9: 1015
Flow Cytometry
Immunoprecipitation Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.