Anti-Mouse CD120a (TNFR1) (Clone 55R-170) – DyLight® 550
Anti-Mouse CD120a (TNFR1) (Clone 55R-170) – DyLight® 550
Product No.: T576
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Clone 55R-170 Target TNFR1 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names CD120α, TNFRSF1A, P55, P60 Isotype IgG Applications FC |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Armenian Hamster Immunogen Purified Recombinant Mouse TNFR1 (>98%) Product Concentration 0.2 mg/ml Formulation This DyLight® 550 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This DyLight® 550 conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Yellow Laser (563 nm) RRIDAB_2832039 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Clone 55R-170 recognizes mouse CD120a. Antigen Distribution CD120a is constitutively expressed in most tissues. Background Tumor Necrosis Factor Receptor Type I (TNFRI) is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-α and TNF-ß (also known as LT-α). The subsequent signaling is known to be important for inducing cytolytic activity, antiviral activity, expression of manganous superoxide dismutase and intercellular adhesion molecule (ICAM), IL-6 mRNA accumulation and NF-ĸB induction. TNFRI carries an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein).
Binding of 55R-170 antibody to TNFRI has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding. Antigen DetailsPubMed NCBI Gene Bank ID UniProt.org Research Area Immunology . Innate Immunity References & Citations1. Dana, R. et al. (2000) Arch Ophthalmol. 118: 1666 2. Donner, DB. et al. (2008) J Immunol. 181: 1288 3. Pasparakis, M. et al. (2008) Nat Immunol. 9: 1015 Technical Protocols |
Formats Available
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Prod No. | Description |
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T583 | |
T249 | |
T575 | |
T576 | |
T577 | |
T579 | |
T581 | |
T248 | |
T250 | |
T950 | |
T440 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.