Anti-Mycobacteria, LAM (MYCO-5936)

Anti-Mycobacteria, LAM (MYCO-5936)

Product No.: M222

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Clone
MYCO-5936
Target
LAM
Formats AvailableView All
Product Type
Hybridoma Monoclonal Antibody
Alternate Names
LAM, lipoarabinomannan, Mtb, TB, Tuberculosis
Isotype
Rabbit IgG
Applications
ELISA
,
IF

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Select Product Size
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Antibody Details

Product Details

Reactivity Species
Mycobacteria sp.
Host Species
Rabbit
Product Concentration
≥1.0 mg/ml
Purity
≥90%
Formulation
Formulated in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1% sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
State of Matter
Liquid
Product Preparation
This monoclonal antibody is purified by protein A chromatography or sequential differential precipitations.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Regulatory Status
Research Use Only
Country of Origin
USA
Shipping
2-8°C Wet Ice
Applications and Recommended Usage?
Quality Tested by Leinco
ELISA: 1:20-1:200,
IF: 1:10-1:50
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Anti-Mycobacteria (Clone MYCO-5936) is specific for the lipoarabinomannan of several Mycobacteria species including Mycobacterium tuberculosis (6 strains), M. bovis, M. smegmatis, M. leprae, M. avium, M. phlei, & M. parafortuitum.
Matched Pair
Best ELISA pair (capture/detection), MYCO-8061/MYCO-5936
Background
Mycobacterium is a diverse genus of bacteria that includes several pathogenic species responsible for causing diseases in humans, most notably Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). Mycobacteria are characterized by their unique cell wall structure, which contains high levels of mycolic acids, making them resistant to many conventional antibiotics. In addition to M. tuberculosis, other medically important species include Mycobacterium leprae, responsible for leprosy, and Mycobacterium avium complex (MAC), causing opportunistic infections in immunocompromised individuals.

Mycobacterium cell walls also contain a glycolipid known as Lipoarabinomannan (LAM), which plays a significant role in pathogenesis. LAM helps the bacteria evade the host immune system and modulate the host's inflammatory response. Additionally, LAM has been used as a diagnostic marker for TB infection, as it can be detected in patient samples such as sputum and urine. Understanding the unique characteristics of Mycobacterium and the role of molecules like LAM is crucial for the development of effective diagnostic tools and therapeutic strategies to combat mycobacterial infections.

Antigen Details

Research Area
Bacteria
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Infectious Disease
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Matched Pair
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Nosocomial
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IVD Raw Material

References & Citations

Indirect Elisa Protocol
IF

Formats Available

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Prod No.
Description
M222
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.