Anti-Mycobacteria, LAM (MYCO-8061)
Anti-Mycobacteria, LAM (MYCO-8061)
Product No.: M221
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Clone MYCO-8061 Target LAM Formats AvailableView All Product Type Hybridoma Monoclonal Antibody Alternate Names LAM, lipoarabinomannan, Mtb, TB, Tuberculosis Isotype Rabbit IgG Applications ELISA , IF |
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Antibody DetailsProduct DetailsReactivity Species Mycobacteria sp. Host Species Rabbit Product Concentration ≥1.0 mg/ml Purity ≥90% Formulation Formulated in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1% sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration. State of Matter Liquid Product Preparation This monoclonal antibody is purified by protein A chromatography or sequential differential precipitations. Storage and Handling This purified antibody is stable when stored at 2-8°C. Do not freeze. Regulatory Status Research Use Only Country of Origin USA Shipping 2-8°C Wet Ice Applications and Recommended Usage? Quality Tested by Leinco ELISA: 1:20-1:200, IF: 1:10-1:50 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Anti-Mycobacteria (Clone MYCO-8061) is specific for the lipoarabinomannan of several Mycobacteria species including Mycobacterium tuberculosis (6 strains), M. bovis, M. smegmatis, M. leprae, M. avium, M. phlei, & M. parafortuitum. Matched Pair Best ELISA pair (capture/detection), MYCO-8061/MYCO-5936 Background Mycobacterium is a diverse genus of bacteria that includes several pathogenic species responsible for causing diseases in humans, most notably Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). Mycobacteria are characterized by their unique cell wall structure, which contains high levels of mycolic acids, making them resistant to many conventional antibiotics. In addition to M. tuberculosis, other medically important species include Mycobacterium leprae, responsible for leprosy, and Mycobacterium avium complex (MAC), causing opportunistic infections in immunocompromised individuals.
Mycobacterium cell walls also contain a glycolipid known as Lipoarabinomannan (LAM), which plays a significant role in pathogenesis. LAM helps the bacteria evade the host immune system and modulate the host's inflammatory response. Additionally, LAM has been used as a diagnostic marker for TB infection, as it can be detected in patient samples such as sputum and urine. Understanding the unique characteristics of Mycobacterium and the role of molecules like LAM is crucial for the development of effective diagnostic tools and therapeutic strategies to combat mycobacterial infections. Antigen DetailsResearch Area Bacteria . Infectious Disease . Matched Pair . Nosocomial . IVD Raw Material References & CitationsTechnical Protocols |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.