Anti-NPFF1 Antibody (56110)
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Antibody DetailsProduct DetailsReactivity Species Human Host Species Rabbit Immunogen N-terminal sequence MEGEPSQPPNSSWPLS and C-terminal sequence CSHLPLTIPAWDI of human NPFF1. Product Concentration Lot Specific Formulation PBS, pH 7.4 with 0.02% sodium azide State of Matter Liquid Product Preparation Purified by immunoaffinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting: use at 1:500-1:1,000 dilution
ELISA: use at 1:1,000-1:5,000 dilution. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Polyclonal Antibody specific to NPFF1 Background The central nervous system octapeptide, neuropeptide FF (NPFF), is believed to play a role in pain modulation and opiate tolerance. Two G protein-coupled receptors, NPFF1 and NPFF2, have been isolated from human and rat central nervous system tissues. Localization of mRNA and binding sites of these receptors in the dorsal horn of the spinal cord, the lateral hypothalamus, the spinal trigeminal nuclei, and the thalamic nuclei suggest a role for NPFF in pain modulation. Antigen DetailsFunction Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. NCBI Gene Bank ID UniProt.org Research Area Neuroscience References & CitationsWB,ELISA |
