Data
Western blot analysis of Parasite Lysates showing detection of HSP70 protein using Rabbit Anti-HSP70 Polyclonal Antibody (11147). Primary Antibody: Rabbit Anti-HSP70 Polyclonal Antibody (11147) at 1:2000. - -
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Antibody DetailsProduct DetailsReactive Species P. Facilparum Host Species Rabbit Immunogen His-tagged C-terminal amino acids 365-681 of P. falciparum Hsp70 (Accession no. M19753). Product Concentration 1.0 mg/ml Formulation PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. Purified by Protein A affinity chromatography. State of Matter Liquid Product Preparation Purified by Protein A affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Regulatory Status For in vitro investigational use only. Not
intended for diagnostic or therapeutic
applications. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting: use at 0.1-1ug/mL. A band of ~70kDa is detected.
These are recommended concentrations. Endusers should determine optimal concentrations for their applications. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity This antibody recognizes P. falciparum
Hsp70. Background Plasmodium falciparum expresses two prominent heat shock proteins: heat shock protein 70 (PfHsp70) and heat shock protein 90 (PfHsp90). Both of these proteins have been implicated in the development and pathogenesis of malaria. PfHsp70-1 is the major cytosolic Hsp70 in Plasmodium falciparum. It is abundantly expressed in the blood stages of the parasite and appears to constitute approx. 1-2% of total parasite protein. It is found in P. falciparum in complexes with PfHsp90 and PfHsp40. The transition from the cold blooded mosquito vector to a host represents physiological stress to the parasite, and, additionally, malaria blood stage infection is characterized by intense fever periods. In recent years, it has become clear that heat shock proteins play an essential role during the parasite's life cycle. UniProt.org Research Area Heat Shock & Stress Proteins References & CitationsTechnical ProtocolsICC IF  Certificate of Analysis |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
