Anti-PSE1/Ku Protein Antibody (70105)
Anti-PSE1/Ku Protein Antibody (70105)
Product No.: 70105
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Clone N9C1 Target PSE1/Ku Protein Formats AvailableView All Product Type Monoclonal Alternate Names EC 3.6.4.-, EC 4.2.99.-, 5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP/AP lyase Ku70, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, DNA repair protein XRCC6, Ku autoantigen protein p70 homolog, Ku70 Isotype Mouse IgG1 Applications WB , Gel Shift |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Proximal sequence element (PSE1) of the human U1 small nuclear RNA extracted from human placenta. Product Concentration Lot Specific Formulation PBS, pH 7.4. State of Matter Liquid Product Preparation Purified by Protein G affinity chromatography Storage and Handling These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco These antibodies work well in Western blot and electrophoretic mobility (gel shift) assays for identifying PSE1 or Ku. They may be used to immuno-deplete Ku protein from protein mixtures prior to specific DNA affinity chromatography. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Mouse Monoclonal Antibody specific to PSE1/Ku Protein. 70105 recognizes the large α subunit (~80-90 kDa) of placental PSE1 and human Ku in
solution and when bound to DNA. Function Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (By similarity). Required for double-strand break repair and V(D)J rUniProtKB:P12956, PubMed:12145306}. NCBI Gene Bank ID UniProt.org Research Area Protein Transcription References & CitationsKnuth MW et al. 1990. J Biol Chem 265: 17911-17920. Technical Protocols Gel Shift Certificate of Analysis |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
