Anti-Quinidine [Clone QD11-228.6.5]
Anti-Quinidine [Clone QD11-228.6.5]
Product No.: 16501
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Clone QD11-228.6.5 Target Quinidine Formats AvailableView All Product Type Monoclonal Isotype Mouse IgG2b Applications ELISA |
Data
Quinidine is a class I antiarrhythmic agent. - -
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Antibody DetailsProduct DetailsReactive Species Quinidine Host Species Mouse Immunogen Quinidine-KLH. Product Concentration Lot Specific Formulation This monoclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.2 - 7.4 with no carrier protein or preservatives added. State of Matter Liquid Product Preparation Antibodies are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. Storage and Handling Upon initial thawing, appropriately aliquot and store at -80°C. For long-term storage, keep at -80°C. Avoid repeated freeze-thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco These antibodies have been qualified for use in ELISA to detect quinidine. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Mouse Monoclonal Antibody specific to Quinidine Background Quinidine is a class I antiarrhythmic agent. Like all other class I antiarrhythmic agents, quinidine primarily works by blocking the fast inward sodium current (INa) which causes the phase 0 depolarization of the cardiac action potential to decrease (decreased Vmax). Quinidine also blocks the slowly inactivating, tetrodotoxin-sensitive Na current, the slow inward calcium current (ICa), the rapid (IKr) and slow (IKs) components of the delayed potassium rectifier current, the inward potassium rectifier current (IKI), the ATP-sensitive potassium channel (IKATP) and Ito. At micromolar concentrations, quinidine inhibits Na /K -ATPase by binding to the same receptor sites as the digitalis glycosides such as ouabain. Research Area Drugs References & CitationsTechnical Protocols Certificate of Analysis |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
