Anti-Streptococcus pneumoniae Type 5 Polysaccharide Antibody (22006)

Streptococcus pneumoniae 5 cells

This monoclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.2 - 7.4 with no carrier protein or preservatives added.

Liquid

Antibodies are purified by a multi-step process including the use of PEG purification chromatography.

Upon initial thawing, appropriately aliquot and store at -80°C. For long-term storage, keep at -80°C. Avoid repeated freeze-thaw cycles.

Next Day 2-8°C

This antibody recognizes pneumococcal type 5 polysaccharide. It does not cross-react with serotypes 14 or 23F.

Streptococcus pneumoniae are Gram-positive bacteria normally found in the upper respiratory tract including the throat and nasal passages. Streptococcus pneumoniae is characterized by a polysaccharide capsule that completely encloses the cell and plays a key role in its virulence. The cell wall of S. pneumoniae is composed of peptidoglycan with teichoic acid attached to every third N-acetylmuramic acid. Lipoteichoic acid is attached via a lipid moiety, and both teichoic and lipoteichoic acid contain phosphorylcholine. Two choline residues may exist on each carbohydrate repeat, which is important to S. pneumoniae because the choline adheres to choline-binding receptors located on human cells.

McDaniel L. et al. 1984 Monoclonal antibodies against protease-sensitive pneumococcal antigens can protect mice from fatal infection with Streptococcus pneumoniae. J Exp Med 160: 386-397.
McDaniel L. et al. 1987 A protective monoclonal antibody that reacts with a novel antigen of pneumococcal teichoic acid. Microbial Pathogenesis 3: 249-260.
Crain MJ et al. 1990 Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular s of Streptococcus pneumoniae. Infection and Immunity 58: 3293-3299.
McDaniel L. et al. 1991 PspA, A surface protein of Streptococcus pneumoniae, is capable of eliciting protection against Pneumococci of more than one capsular type. Infection and Immunity 59: 222-228.