Anti-Syntaxin

Pricing & Details

Product No.S100
Clone
HPC-1
Protein
Syntaxin
Formats AvailableView All
Product Type
Monoclonal Antibody
Isotype
Mouse
IgG1
Applications
IHC FFPE
,
IP
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
S100-0.125 mg
0.125 mg
$254.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Product Concentration
0.5 mg/ml
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Anti-Syntaxin (Clone HPC-1)recognizes a (Mr 35 kD) polypeptide on the cell membrane of amacrine cells.1 In hippocampus, this antibody recognizes the stratum radiatum, the layer formed by the fibers of dentate granule cells. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Syntaxins (syntaxin isotypes 1-4) are membrane integrated Q-SNARE proteins participating in exocytosis. Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. Direct syntaxin-channel interaction is a suitable molecular mechanism for proximity between the fusion machinery and the gates of Ca2 + entry during depolarization of the presynaptic axonal boutons.

Antigen Details

Protein
PubMed
Research Area
Cell Biology
.
Neuroscience
.
Synaptic Biology

References & Citations

1. Barnstable, C. J. et al. (1985) Dev. Brain Res. 20:286 2. Inoue, A. et al. (1992) J. Biol. Chem. 267:10613
IHC
Immunoprecipitation Protocol
General Western Blot Protocol

Formats Available

Prod No.
Description
S100
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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