Anti-TRIP230 Antibody (3342)
Anti-TRIP230 Antibody (3342)
Product No.: 3342
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Clone 10G5 Target TRIP230 Formats AvailableView All Product Type Monoclonal Alternate Names TR-interacting protein 11, TRIP-11, Clonal evolution-related gene on chromosome 14 protein, Golgi-associated microtubule-binding protein 210, GMAP-210, Trip230 Isotype Mouse IgG1 Applications ICC , IF , IP , WB |
Data
Immunofluorescence analysis of methanol-fixed HeLa, using TRIP230(3342) antibody at 1:100 dilution. - -
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen GST fusion protein corresponding to aa 1099-1372 of Trip230 expressed in E. coli. Product Concentration Lot Specific Formulation PBS, pH 7.4 State of Matter Liquid Product Preparation Purified by Protein G affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -70°C. Avoid multiple freeze- thaw cycles. Regulatory Status Research Use Only Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting,
Immunoprecipitation: use at 1-5 ug/mL. Positive control: MCF7, HBL100, and T24 cells and recombinant fusion protein. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity This antibody recognizes human Trip230, a 230 kD protein. The gene for Trip230 is located on chromosome 14q31 in a region associated with genetic alterations and thyroid hormone response abnormalities. Trip230 interacts with Retinoblasoma Protein (Rb) and thyroid hormone receptor using two distinct domains. Function Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {PubMed:10189370, PubMed:25473115, PubMed:25717001, PubMed:30728324, PubMed:9256431}. NCBI Gene Bank ID UniProt.org Research Area Cancer Research References & CitationsChen, Y et al. 1999. PNAS (USA) 96: 4443-4448 Chang, KH et al. 1997. PNAS (USA) 94: 9040-9045. Technical ProtocolsICC IF   Certificate of Analysis |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
