Anti-Viral CCI (Clone 112811)

Anti-Viral CCI (Clone 112811)

Product No.: C1449

[product_table name="All Top" skus="C1449"]

- -
- -
Clone
112811
Target
CC Chemokine Inhibitor
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
P35
Isotype
IgG1
Applications
WB

- -
- -
Select Product Size
- -
- -

Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Mouse
Immunogen
Sf 21-Derived Recombinant Viral CCI
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Formulation
This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Storage and Handling
The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Country of Origin
USA
Shipping
Next Day Ambient
Applications and Recommended Usage?
Quality Tested by Leinco
Western Blotting: To detect Mouse CCI this monoclonal antibody can be used at a concentration of 1-2 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:M114 and a chromogenic substrate such as PN:T343. The detection limit for Mouse CCI is 2 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Mouse Anti-Mouse CC chemokine inhibitor (CCI) (Clone 112811) recognizes an epitope on Mouse CCI. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Viral C-C chemokine inhibitor (vCCI) is a secreted, poxvirus-encoded C-C chemokine inhibitor1 that binds tightly and inhibit the action of many CC chemokines.2 VCCI can act as a potent anti-inflammatory therapeutic.3

References & Citations

1. Don C et al. (1996) Proc Natl Acad Sci USA 96: 12379 2. LiWang PJ et al. (2006) Proc Natl Acad Sci USA 103: 13985 3. Patricia J Liwang et al. (2006) NIAID
General Western Blot Protocol

Certificate of Analysis

Formats Available

- -
- -
Prod No.
Description
C1449
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.