Anti-Zika, Env (Clone ZIKA-9670) – Purified No Carrier Protein
Anti-Zika, Env (Clone ZIKA-9670) – Purified No Carrier Protein
Product No.: Z207
- -
- -
Clone ZIKA-9670 Target ZIKV E (Envelope) Formats AvailableView All Product Type Hybridoma Monoclonal Antibody Alternate Names Envelope, E protein Isotype Mouse IgG1 κ Applications ELISA , Lateral Flow |
- -
- -
Antibody DetailsProduct DetailsReactivity Species Zika Virus Host Species Mouse Immunogen Zika Envelope Protein Product Concentration ≥1.0 mg/ml Formulation Formulated in 0.015 M phosphate buffered saline (0.85% NaCl), pH 7.2 and contains 0.05% sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration. State of Matter Liquid Product Preparation This monoclonal antibody is purified by ion exchange chromatography. Storage and Handling This purified antibody is stable when stored at 2-8°C. Do not freeze. Regulatory Status Research Use Only Shipping 2-8°C Applications and Recommended Usage? Quality Tested by Leinco ELISA, Lateral Flow Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Anti-Zika virus (Clone ZIKA-9670) is specific for Zika virus envelope (E) protein. Background Zika virus (ZIKV) infection during pregnancy is a global public health problem 1, linked causally to severe fetal abnormalities 2. Prophylactic antibodies may prove useful in treating pregnant patients or for designing epitope-specific vaccines 1.
ZIKV is a mosquito-transmitted flavivirus that encodes a single polyprotein with an ~11 kb positive-sense RNA open reading frame 1. The polyprotein is cleaved into seven non-structural (NS) proteins and three structural proteins (capsid (C), pre-membrane (prM), and envelope (E)). C forms a nucleocapsid. prM complexes with E to facilitate folding and prevent premature fusion to host membranes. E is responsible for viral assembly, attachment, entry, and fusion 1,3 and is a major target of neutralizing antibody research 3. Mature ZIKV virions incorporate 180 copies each of the E and M proteins 4,5. Antigen DetailsResearch Area Category B Pathogens . Infectious Disease . Matched Pair . Viral . IVD Raw Material References & Citations1. Zhao H, Fernandez E, Dowd KA. et al. (2016). Cell. 166(4):1016-1027. 2. Brasil P, Pereira Jr JP, Moreira ME. et al. (2016). N Engl J Med. 375(24):2321-2334. 3. Dai L, Song J, Lu X. et al. (2016). 19(5):696-704. 4. Kostyuchenko VA, Lim EX, Zhang S. et al. (2016). Nature. 533(7603):425-428. 5. Sirohi D, Chen Z, Sun L. et al. (2016). Science. 352(6284):467-470. Technical Protocols |
Formats Available
