Anti-Zika, Env (Clone ZIKA-9670) – Purified No Carrier Protein

Anti-Zika, Env (Clone ZIKA-9670) – Purified No Carrier Protein

Product No.: Z207

- -
- -
Clone
ZIKA-9670
Target
ZIKV E (Envelope)
Formats AvailableView All
Product Type
Hybridoma Monoclonal Antibody
Alternate Names
Envelope, E protein
Isotype
Mouse IgG1 κ
Applications
ELISA
,
Lateral Flow

- -
- -
Select Product Size
- -
- -

Antibody Details

Product Details

Reactivity Species
Zika Virus
Host Species
Mouse
Immunogen
Zika Envelope Protein
Product Concentration
≥1.0 mg/ml
Formulation
Formulated in 0.015 M phosphate buffered saline (0.85% NaCl), pH 7.2 and contains 0.05% sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
State of Matter
Liquid
Product Preparation
This monoclonal antibody is purified by ion exchange chromatography.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Regulatory Status
Research Use Only
Shipping
2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
ELISA,
Lateral Flow
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Anti-Zika virus (Clone ZIKA-9670) is specific for Zika virus envelope (E) protein.
Background
Zika virus (ZIKV) infection during pregnancy is a global public health problem 1, linked causally to severe fetal abnormalities 2. Prophylactic antibodies may prove useful in treating pregnant patients or for designing epitope-specific vaccines 1.

ZIKV is a mosquito-transmitted flavivirus that encodes a single polyprotein with an ~11 kb positive-sense RNA open reading frame 1. The polyprotein is cleaved into seven non-structural (NS) proteins and three structural proteins (capsid (C), pre-membrane (prM), and envelope (E)). C forms a nucleocapsid. prM complexes with E to facilitate folding and prevent premature fusion to host membranes. E is responsible for viral assembly, attachment, entry, and fusion 1,3 and is a major target of neutralizing antibody research 3. Mature ZIKV virions incorporate 180 copies each of the E and M proteins 4,5.

Antigen Details

Research Area
Category B Pathogens
.
Infectious Disease
.
Matched Pair
.
Viral
.
IVD Raw Material

References & Citations

1. Zhao H, Fernandez E, Dowd KA. et al. (2016). Cell. 166(4):1016-1027.
2. Brasil P, Pereira Jr JP, Moreira ME. et al. (2016). N Engl J Med. 375(24):2321-2334.
3. Dai L, Song J, Lu X. et al. (2016). 19(5):696-704.
4. Kostyuchenko VA, Lim EX, Zhang S. et al. (2016). Nature. 533(7603):425-428.
5. Sirohi D, Chen Z, Sun L. et al. (2016). Science. 352(6284):467-470.
Indirect Elisa Protocol
Lateral Flow

Formats Available

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.