Anti-Zika, NS1 (Clone ZIKA-4592) – Purified No Carrier Protein

Recombinant Zika NS1 Protein

Formulated in 0.015 M phosphate buffered saline (0.85% NaCl), pH 7.2 and contains 0.05% sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

Liquid

This monoclonal antibody is purified by ion exchange chromatography.

This purified antibody is stable when stored at 2-8°C. Do not freeze.

Research Use Only

2 – 8° C Wet Ice

Anti-Zika virus (Clone ZIKA-4592) is specific for the non-structural protein 1 (NS1) of Zika virus.

Zika virus (ZIKV) infection during pregnancy is a global public health problem ¹ linked causally to severe fetal abnormalities ². Prophylactic antibodies may prove useful in treating pregnant patients or for designing epitope-specific vaccines ¹.

ZIKV is a mosquito-transmitted flavivirus that encodes a single polyprotein with an ~11 kb positive-sense RNA open reading frame ¹. The polyprotein is cleaved into seven non-structural (NS) proteins and three structural proteins (capsid (C), pre-membrane (prM), and envelope (E)). C forms a nucleocapsid. prM complexes with E to facilitate folding and prevent premature fusion to host membranes. Nonstructural Protein 1 (NS1) plays a crucial role in viral replication and immune evasion ⁶.

1. Zhao H, Fernandez E, Dowd KA. et al. (2016). Cell. 166(4):1016-1027.
2. Brasil P, Pereira Jr JP, Moreira ME. et al. (2016). N Engl J Med. 375(24):2321-2334.
3. Dai L, Song J, Lu X. et al. (2016). 19(5):696-704.
4. Kostyuchenko VA, Lim EX, Zhang S. et al. (2016). Nature. 533(7603):425-428.
5. Sirohi D, Chen Z, Sun L. et al. (2016). Science. 352(6284):467-470.
6. Bailey MJ, Duehr J, Dulin H. et al. (2018). Nat Commun. 9(4560).