Eotaxin Blocking Peptide

This peptide sequence is located at amino acids 83 to 97 of Human Eotaxin protein.

This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.

Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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15 amino acids near the carboxy terminus of human Eotaxin.

The CC-chemokine eotaxin is a potent eosinophil chemoattractant that stimulates recruitment of eosinophils from the blood to sites of allergic inflammation. ¹
Eotaxin and related molecules are potentially important endogenous signaling substances in allergic reactions. ² Eotaxin plays an important role not only by attracting eosinophils to the site of inflammation but also by damaging tissue by its capacity to induce the release of reactive oxygen species. ³

1. Rankin SM. et al. (1998) Blood. 91:2240 2. Williams TJ. et al. (1993) Biochem Biophys Res Commun. 197:1167 3. Kapp A. et al. (1996) Eur J Immunol. 26:1919