IL-1RAcP (Interleukin-1 Receptor Accessory) Blocking Peptide

This peptide sequence is located at amino acids 549 to 569 of Human IL-1 RAcP protein.

This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.

Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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21 amino acids near the carboxy terminus of human IL-1RAcP.

IL-1R accessory protein (IL-1RAcP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, necessary to link events on the plasma membrane level to downstream signaling pathways, allowing IL-1-dependent activation of transcription factors and gene expression.¹ IL-1R AcP represents a novel target for blocking IL-1 function in human disease.²

1. Martin MU et al. (1997) J Biol Chem. 272: 7727 2. Labow MA et al. (1998) J Immunol. 161: 5614