IL-1RAcP (Interleukin-1 Receptor Accessory) Blocking Peptide

IL-1RAcP (Interleukin-1 Receptor Accessory) Blocking Peptide

Product No.: I-320

[product_table name="All Top" skus="I-320"]

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Target
Interleukin-1 Receptor Accessory Protein
Product Type
Blocking Peptide
Alternate Names
IL1RAP

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Antibody Details

Product Details

Reactive Species
Human
Product Concentration
0.2 mg/ml
Amino Acid Location
This peptide sequence is located at amino acids 549 to 569 of Human IL-1 RAcP protein.
Formulation
This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.
Storage and Handling
Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Amino Acid Sequence
21 amino acids near the carboxy terminus of human IL-1RAcP.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Background
IL-1R accessory protein (IL-1RAcP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, necessary to link events on the plasma membrane level to downstream signaling pathways, allowing IL-1-dependent activation of transcription factors and gene expression.1 IL-1R AcP represents a novel target for blocking IL-1 function in human disease.2

Antigen Details

References & Citations

1. Martin MU et al. (1997) J Biol Chem. 272: 7727 2. Labow MA et al. (1998) J Immunol. 161: 5614
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