Recombinant Human CD30

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Pricing & Details

Product. No.C1357
Alternate Names
TNFRSF8, D1S166E, KI-1, CD153
Expression Host
NS0 cells
Species
Human
Prod No.
Size
Price
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Qty
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C1357-100 µg
100 µg
$445.00
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Background

CD30/TNFRSF8, a type I transmembrane glycoprotein belonging to the TNF receptor superfamily and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. CD30 is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma but not in seminoma and is thus is a useful marker in distinguishing between these germ cell tumors.

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human CD30 was determined by its ability to bind rhCD30 Ligand. Immobilized rhCD30 Ligand at 100 ng/ml (100 μl/well) can bind rhCD30/Fc with a linear range of 3.125-200 ng/ml in a functional ELISA.
Fusion Protein Tag
Fc Fusion Protein
Expression Host
NS0 cells
Protein Accession No.
Amino Acid Sequence
fp qdrpfedtch gnpshyydka vrrccyrcpm glfptqqcpq rptdcrkqce pdyyldeadr ctacvtcsrd dlvektpcaw nssrvcecrp gmfcstsavn scarcffhsv cpagmivkfp gtaqkntvce paspgvspac aspenckeps sgtipqakpt pvspatssas tmpvrggtrl aqeaaskltr apdspssvgr pssdpglspt qpcpegsgdc rkqcepdyyl deagrctacv scsrddlvek tpcawnssrt cecrpgmica tsatnscarc vpypicaaet vtkpqdmaek dttfeapplg tqpdcnptpe ngeapastsp tqsllvdsqa sktlpiptsa pvalsstgki egrmdpkscd kthtcppcpa pellggpsvf lfppkpkdtl misrtpevtc vvvdvshedp evkfnwyvdg vevhnaktkp reeqynstyr vvsvltvlhq dwlngkeykc kvsnkalpap iektiskakg qprepqvytl ppsrdeltkn qvsltclvkg fypsdiavew esngqpenny kttppvldsd gsfflysklt vdksrwqqgn vfscsvmhea lhnhytqksl slspgkhhhh hh
N-terminal Sequence Analysis
Phe19
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human CD30 is Mr 66 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 100-125 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Kim, JT. et al. (2017) J Microbiol Immunol Infect. 50(2):145-152.
2. Abken, H. et al. (2019) Mol Ther. 27(10):1825-1835.
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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