Chemokine (C-X-C motif) ligand 14 (CXCL14) is a small cytokine belonging to the CXC chemokine family that is also known as BRAK (for breast and kidney-expressed chemokine).1 CXCL14 is known to be a chemoattractant for monocyte and dendritic cells.2 CXCL14 might play a pivotal role in the pathobiology of pancreatic cancer, probably by regulating cancer invasion.3
>97% by SDS-PAGE and analyzed by silver stain.
<0.01EU/µg as determined by the LAL method
The biological activity of Human BRAK was determined by its ability to induce calcium flux of prostaglandin E2 treated THP-1 cells (Kurth, I. et al., 2001, J. Exp. Med. 194:855). 0.25 μg/mL of rhCXCL14 can significantly induce calcium flux.
Protein Accession No.
Amino Acid Sequence
skckcsrkgp kirysdvkkl emkpkyphce ekmviittks vsryrgqehc lhpklqstkr fikwynawne krrvyee
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human CXCL14 is Mr 9.4 kDa.
This recombinant protein solution was 0.2 µm filtered and formulated in modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 with no calcium, magnesium, or preservatives present.
Storage and Stability
Working aliquots of this recombinant protein solution are stable for up to twelve months at -20°C to -70°C in a manual defrost freezer. Upon thawing, in the presence of a carrier protein, this recombinant protein can be stored at 2° - 8°C for one month without detectable loss of activity. For long-term storage, aliquot and freeze at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles.
Country of Origin
NCBI Gene Bank
References & Citations
1. Moser, B. et al. (2004) Cytokine 44: 248
2. Chihara, K. et al. (2007) Biochem Biophys Res Commun. 364: 1037
3. Friess, H. et al. (2008) Cancer Lett. 259: 209
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.