Recombinant Human Eotaxin-2

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Pricing & Details

Product. No.E112
Alternate Names
CCL24, MPIF-2, CkB-6, SCYA24
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
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E112-25 µg
25 µg
$249.00
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Step: 1

Background

Eotaxin-2 is a CC chemokine that is a specific agonist for the chemokine receptor CCR3. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 induces chemotaxis of eosinophils as well as basophils and the release of histamine and leukotriene C4 from basophils. Eotaxin-2 has the same efficacy as eotaxin, but is somewhat less potent. 1 Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells.

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human Eotaxin-2 was determined by its ability to chemoattract hCCR-3 transfected rat myeloid Y3 cells and mCCR-3 transfected BaF/3 cells. The expected ED50 for this effect is typically 0.01 - 0.05 μg/ml for both assays.
Expression Host
E. coli
Protein Accession No.
AAB51135.1
Amino Acid Sequence
vvip spccmffvsk ripenrvvsy qlssrstclk ggvifttkkg qqfcgdpkqe wvqrymknld akqkkaspra ravavkgpvq rypgnqttc
N-terminal Sequence Analysis
Val27
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human Eotaxin-2 is Mr 10.6 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Baggiolini, M. et al. (1997) J. Exp. Med. 185: 2171
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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