Eotaxin-2 is a CC chemokine that is a specific agonist for the chemokine receptor CCR3. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 induces chemotaxis of eosinophils as well as basophils and the release of histamine and leukotriene C4 from basophils. Eotaxin-2 has the same efficacy as eotaxin, but is somewhat less potent. 1 Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells.
>95% by SDS-PAGE and analyzed by silver stain.
<0.01EU/µg as determined by the LAL method
The biological activity of Mouse Eotaxin-2 was determined by its ability to induce chemotaxis of mouse BaF/3 cells transfected with mCCR3. The expected ED50= 150 - 600 ng/ml.
Protein Accession No.
Amino Acid Sequence
idsvtip sscctsfisk kipenrvvsy qlangsicpk agvifitkkg hkictdpkll wvqrhiqkld akknqpskga kavrtkfavq rrrgnstev
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse Eotaxin-2 is Mr 10.6 kDa.
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank
References & Citations
1. Baggiolini, M. et al. (1997) J. Exp. Med. 185: 2171
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.