Recombinant Human IL-13 Rα1

Interleukin 13 receptor alpha 1 (IL13Rα1), also known as CD213A1, is a subunit of the IL-13 receptor, and binds IL-13 with a low affinity by itself. IL-13 is capable of binding two types of receptor (1). One is the heterodimer composed of the IL13Rα1 and the IL4Rα , which transduces the IL-13 signals. The other is IL13Rα2 which acts as a non-signaling "decoy" receptor (2). IL13Rα1 forms a functional receptor complex for IL-13 with IL4Rα, a subunit shared by IL-13 and IL-4 receptors, transducing an IL13-dependent proliferative signal (3). IL13Rα1 also has also been shown to serve as an alternate accessory protein to the common cytokine receptor gamma chain for IL-4 signaling, but cannot replace the function of gamma C in allowing enhanced IL-2 binding activity (4). IL13Rα1 can bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL-13 and IL-4 (5). Overexpression of IL13Rα1 may play some roles in the pathogenesis of chronic stage of psoriasis.

Fc Fusion Protein

Q5JSL4

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Ala27

Lyophilized

The predicted molecular weight of Recombinant Human IL-13 Rα is Mr 64 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 110 kDa.

64

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Caput, D. et al. (1996) J. Biol. Chem. 271:16921
2. Donaldson, DD. et al. (1998) J. Immunol. 161:2317
3. Hilton, DJ. et al. (1996) Proc. Natl. Acad. Sci. (USA) 93:497
4. Zhang, JG. et al. (1997) J. Biol. Chem. 272:9474
5. Orchansky, PL. et al. (1999) J. Biol. Chem. 274:0818