Recombinant Mouse IL-13 Rα1

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Pricing & Details

Product. No.I-564
Alternate Names
Interleukin-13 Receptor Alpha 1, IL13RA1, CD213A1, IL-13Ra, NR4
Expression Host
NS0 cells
Species
Mouse
Prod No.
Size
Price
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Qty
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I-564-200 µg
200 µg
$399.00
In stock
Max:
Min: 1
Step: 1

Background

Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1) is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL-13Ralpha1is essential for allergen-induced airway hyperreactivity and mucus hypersecretion.1

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Fusion Protein Tag
Fc Fusion Protein
Expression Host
NS0 cells
Protein Accession No.
Amino Acid Sequence
atevqppvtn lsvsvenlct iiwtwsppeg aspnctlryf shfddqqdkk iapethrkee lpldekiclq vgsqcsanes ekpsplvkkc isppegdpes avtelkciwh nlsymkcswl pgrntspdth ytlyywyssl eksrqceniy regqhiacsf kltkvepsfe hqnvqimvkd nagkirpsck ivsltsyvkp dpphikhlll kngallvqwk npqnfrsrcl tyevevnntq tdrhnileve edkcqnsesd rnmegtscfq lpgvladavy tvrvrvktnk lcfddnklws dwseaqsigk eqnstdiegr pkscdkthtc ppcpapellg gpsvflfppk pkdtlmisrt pevtcvvvdv shedpevkfn wyvdgevehn aktkpreeqy nstyrvvsvl tvlhqdwlng keykckvsnk alpapiekti skakgqprep qvytlppsrd eltknqvslt clvkgfypsd iavewesngq pennykttpp vldsdgsffl yskltvdksr wqqgnvfscs vmhealhnhy tqkslslspg khhhhhh
N-terminal Sequence Analysis
Ala25
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse IL-13 Rα1 is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100-120 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Caput, D. et al. (1996) J. Biol. Chem. 271:16921
2. Donaldson, DD. et al. (1998) J. Immunol. 161:2317
3. Hilton, DJ. et al. (1996) Proc. Natl. Acad. Sci. (USA) 93:497
4. Zhang, JG. et al. (1997) J. Biol. Chem. 272:9474
5. Orchansky, PL. et al. (1999) J. Biol. Chem. 274:0818
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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