Recombinant Human MIP-3β

Macrophage inflammatory protein-3beta (MIP-3beta) is a non-glycosylated polypeptide and member of the B-chemokine (C-C) family of cytokines. It plays an important role in the inflammatory response of human T cells and tissue macrophages. MIP-3beta is a potential chemoattractant for endometrial natural killer cells.¹ It may be important in trafficking of T cells in thymus, and T cell and B cell migration to secondary lymphoid organs.²

The biological activity of Human MIP-3β was determined by its ability to chemoattract cultured (5 - 10 days) human lymphocytes or human T-lymphoblastoid CEM NKr cells (Howell, D.N. et al.,1985, J. Immunol. 134:971-976). The expected ED₅₀ is typically 0.1 - 0.3 μg/ml and 0.2 - 0.6 μg/ml, respectively.

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Gly22

Lyophilized

The predicted molecular weight of Recombinant Human MIP-3β is Mr 8.8 kDa.

8.8

This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Honjo, H. et al. (2004) Fertil Steril. 1: 876
2. Broxmeyer, HE. et al. (1998) J Immunol. 160: 2418