Macrophage inflammatory protein-3beta (MIP-3beta) is a non-glycosylated polypeptide and member of the B-chemokine (C-C) family of cytokines. It plays an important role in the inflammatory response of human T cells and tissue macrophages. MIP-3beta is a potential chemoattractant for endometrial natural killer cells.1 It may be important in trafficking of T cells in thymus, and T cell and B cell migration to secondary lymphoid organs.2
>97% by SDS-PAGE and analyzed by silver stain.
<0.01 EU/µg as determined by the LAL method
The biological activity of Mouse MIP-3β was determined by measured by its ability to chemoattract 5 - 10 day cultured human lymphocytes and BaF/3 cells transfected with hCCR-7. The expected ED50 for these effects are typically 0.03 - 0.1 μg/ml and 3 - 15 ng/ml, respectively.
Protein Accession No.
Amino Acid Sequence
ganda edcclsvtqr pipgnivkaf ryllnedgcr vpavvfttlr gyqlcappdq pwvdriirrl kkssaknkgn strrspvlg
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse MIP-3β is Mr 9.4 kDa.
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank
References & Citations
1. Honjo, H. et al. (2004) Fertil Steril. 1: 876
2. Broxmeyer, HE. et al. (1998) J Immunol. 160: 2418
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.