Recombinant Mouse MIP-3β

Macrophage inflammatory protein-3beta (MIP-3beta) is a non-glycosylated polypeptide and member of the B-chemokine (C-C) family of cytokines. It plays an important role in the inflammatory response of human T cells and tissue macrophages. MIP-3beta is a potential chemoattractant for endometrial natural killer cells.¹ It may be important in trafficking of T cells in thymus, and T cell and B cell migration to secondary lymphoid organs.²

The biological activity of Mouse MIP-3β was determined by measured by its ability to chemoattract 5 - 10 day cultured human lymphocytes and BaF/3 cells transfected with hCCR-7. The expected ED₅₀ for these effects are typically 0.03 - 0.1 μg/ml and 3 - 15 ng/ml, respectively.

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Gly26

Lyophilized

The predicted molecular weight of Recombinant Mouse MIP-3β is Mr 9.4 kDa.

9.4

This recombinant protein was lyophilized from a 0.2 μm filtered solution in 30% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Honjo, H. et al. (2004) Fertil Steril. 1: 876
2. Broxmeyer, HE. et al. (1998) J Immunol. 160: 2418