Recombinant Human RANTES (Mucin Stalk Chimera)

Recombinant Human RANTES (Mucin Stalk Chimera)

Product No.: R1260

[product_table name="All Top" skus="R1260"]

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Alternate Names
CCL5, D17S136E, MGC17164, SCYA5, SIS-Delta, TCP228
Product Type
Recombinant Protein
Expression Host
NS0 Cells
Species
Human

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Background

RANTES also known as Chemokine (C-C motif) ligand 5 (CCL5), a CC-chemokine1 is an important mediators of the immune and inflammatory response.2 It is also a potent chemoattractant for T cells 3 and eosinophils.4 RANTES is involved in many inflammatory diseases, for example, bronchial asthma, delayed-type hypersensitivity reactions, viral infections, arthritis, chronic eosinophilic pneumonia, and idiopathic interstitial pneumonia.5

Protein Details

Purity
>90% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
< 1.0 EU/mg as determined by the LAL method
Fusion Protein Tag
Histidine Tag
Protein Accession No.
P13501 (CCL5) & P78423 (CX3CL1 Mucin-like Stalk)
Amino Acid Sequence
(Human RANTES) spyssdttpc cfayiarplp rahikeyfyt sgkcsnpavv fvtrknrqvc anpekkwvre yinslemsgs (Human Fractalkine Mucin-like Stalk) fekqigevkp rttpaaggmd esvvlepeat gesssleptp ssqeaqralg tspelptgvt gssgtrlppt pkaqdggpvg telfrvppvs taatwqssap hqpgpslwae aktseapstq dpstqastas spapeenaps egqrvwgqgq sprpensler eemgpvpaht dafqdwgpgs mahvsvvpvs segtpsrepv asgswtpkae epihatmdpq rlgvlitpvp daqaatrrqk qnhhhhhh
N-terminal Sequence Analysis
Ser24
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human RANTES is Mr 34 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 85-105 kDa.
Predicted Molecular Mass
34
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient

References & Citations

1. Lee, SC. et al. (2004) J Neurochem. 90: 297
2. Borkowski, J. et al. (2004) Arch Immunol Ther Exp (Warsz) 52: 201
3. Geiger, H. et al. (2005) Kidney Blood Press Res 28: 48
4. Hirata, I. et al.(2009) Dig Dis Sci. 54(6):1247-52.
5. Emilie, D. et al. (1994) J Exp Med. 179: 1689
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.