Anti-Mouse RANTES (Clone 53405)

Anti-Mouse RANTES (Clone 53405)

Product No.: C1426

[product_table name="All Top" skus="C1426"]

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Clone
53405
Target
RANTES
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
CCL5, D17S136E, MGC17164, SCYA5, SIS-Delta, TCP228
Isotype
IgG2a
Applications
ICC
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N

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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Rat
Immunogen
Purified Recombinant Mouse RANTES (>98%)
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Formulation
This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Storage and Handling
The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Country of Origin
USA
Shipping
Next Day Ambient
Additional Applications Reported In Literature ?
Neutralization: This antibody is useful for neutralization of Mouse CCL5 bioactivity. The antibody dose required to neutralize 50% (ND50) of the biological activity of Mouse CCL5 (at 0.05 ng/ml) is 0.1 - 0.5 µg/ml.
Immunocytochemistry: Suitable for use at concentration of 8-25 µg/mL.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rat Anti-Mouse Regulation Upon Activation Normal T Cell Express Sequence (RANTES) (Clone 53405) recognizes an epitope on Mouse RANTES. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
RANTES also known as Chemokine (C-C motif) ligand 5 (CCL5), a CC-chemokine1 is an important mediators of the immune and inflammatory response.2 It is also a potent chemoattractant for T cells 3 and eosinophils.4 RANTES is involved in many inflammatory diseases, for example, bronchial asthma, delayed-type hypersensitivity reactions, viral infections, arthritis, chronic eosinophilic pneumonia, and idiopathic interstitial pneumonia.5

Antigen Details

PubMed

References & Citations

1. Lee, SC. et al. (2004) J Neurochem. 90: 297
2. Borkowski, J. et al. (2004) Arch Immunol Ther Exp (Warsz) 52: 201
3. Geiger, H. et al. (2005) Kidney Blood Press Res 28: 48
4. Hirata, I. et al.(2009) Dig Dis Sci. 54(6):1247-52.
5. Emilie, D. et al. (1994) J Exp Med. 179: 1689

Formats Available

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Prod No.
Description
C1426
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.