Recombinant Mouse RANTES

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Pricing & Details

Product. No.R135
Alternate Names
CCL5, D17S136E, MGC17164, SCYA5, SIS-Delta, TCP228
Expression Host
E. coli
Species
Mouse
Prod No.
Size
Price
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Qty
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R135-25 µg
25 µg
$309.00
In stock
Max:
Min: 1
Step: 1

Background

RANTES also known as Chemokine (C-C motif) ligand 5 (CCL5), a CC-chemokine1 is an important mediators of the immune and inflammatory response.2 It is also a potent chemoattractant for T cells 3 and eosinophils.4 RANTES is involved in many inflammatory diseases, for example, bronchial asthma, delayed-type hypersensitivity reactions, viral infections, arthritis, chronic eosinophilic pneumonia, and idiopathic interstitial pneumonia.5

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Mouse RANTES was determined by its ability to chemoattract 2 day cultured human monocytes or mouse BaF3 cells transfected with human CCR5. The expected ED50 for these effects are typically 30 - 100 ng/ml and 7 - 35 ng/ml, respectively.
Expression Host
E. coli
Protein Accession No.
Q5XZF2
Amino Acid Sequence
spygsdttpc cfaylslalp rahvkeyfyt sskcsnlavv fvtrrnrqvc anpekkwvqe yinylems
N-terminal Sequence Analysis
Ser24
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse RANTES is Mr 7.9 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA) with trehalose.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Lee, SC. et al. (2004) J Neurochem. 90: 297
2. Borkowski, J. et al. (2004) Arch Immunol Ther Exp (Warsz) 52: 201
3. Geiger, H. et al. (2005) Kidney Blood Press Res 28: 48
4. Hirata, I. et al.(2009) Dig Dis Sci. 54(6):1247-52.
5. Emilie, D. et al. (1994) J Exp Med. 179: 1689
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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