Recombinant Mouse Fractalkine (FKN)

Recombinant Mouse Fractalkine (FKN)

Product No.: F1036

[product_table name="All Top" skus="F1036"]

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Alternate Names
CX3CL1, NTN, ABCD-3, C3Xkine, CXC3, CXC3C, NTT, SCYD1, Neurotactin, FKN
Product Type
Recombinant Protein
Expression Host
sf Insect Cells
Species
Mouse

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Product Size
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Background

Fractalkine (FKN) is a transmembrane mucin-chemokine hybrid molecule expressed on activated endothelium1 that mediates attachment and firm adhesion of T cells, monocytes and NK cells.2 FKN plays an important proinflammatory role in rheumatoid arthritis (RA) pathogenesis as characterized by induction of synovial angiogenesis, chemotaxis, activation of monocytes and T cells as well as the stimulation of proliferation and synthesis of matrix degrading enzymes (matrix metalloproteinases, MMP) in synovial fibroblasts. Fractalkine thus may represent a novel target molecule for therapeutic intervention in RA.3 FKN is also an essential biomarker for predicting the prognosis of patients with colorectal cancer (CRC).4

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Fusion Protein Tag
Histidine Tag
Protein Accession No.
Amino Acid Sequence
qhlgmt kceimcgkmt sripvallir yqlnqescgk raivlettqh rrfcadpkek wvqdamkhld hqaaaltkng gkfekrvdnv tpgitlatrg lspsaltkpe satledlale lttisqearg tmgtsqeppa avtgsslsts eaqdagltak pqsigsfeaa disttvwpsp avyqsgsssw aeekatesps ttapspqvst tspstpeenv gsegqppwvq gqdlspeksl gseeinpvht dnfqergpgn tvhpsvapis seetpspelv asgsqapkie epihatadpq klsvlitpvp dtqaatrhhh hhh
N-terminal Sequence Analysis
Gln25 predicted
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse Fractalkine is Mr 34 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 90 kDa.
Predicted Molecular Mass
34
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Patel, DD. et al. (1998) J Exp Med. 188: 1413
2. Hwang, ST. et al. (1999) Eur J Immunol. 29: 2551
3. Muller, GA. et al. (2008) Z Rheumatol. 67: 424
4. Mori, M. et al. (2005) Int J Oncol. 26: 41
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.