Recombinant Mouse MAdCAM-1

Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a multifunctional type l transmembrane adhesion molecule that is expressed selectively at venular sites of lymphocyte extravasation into mucosal lymphoid tissues and lamina propria, where it directs local lymphocyte trafficking.¹ MAdCAM-1 is involved in the normal recirculation of lymphocytes between the blood and the gastrointestinal tract.² MAdCAM-1 may be a relevant tissue-specific therapeutic target for the modulation of inflammatory bowel disease activity.³

Fc Fusion Protein

qsfqvnppes evavamgtsl qitcsmscde gvarvhwrgl dtslgsvqtl pgssilsvrg mlsdtgtpvc vgscgsrsfq hsvkilvyaf pdqlvvspef lvpgqdqvvs ctahniwpad pnslsfalll geqrlegaqa lepeqeeeiq eaegtplfrm tqrwrlpslg tpappalhcq vtmqlpklvl thrkeipvlq sqtspkppnt tsaepyilts sstaeavstg lnittlpsap pypklsprtl ssegpcrpki hqdleagwel lceascgpgv tvrwtlapgd latyhkreag aqawlsvlpp gpmvegwfqc rqdpggqvtn lyvpgqvtpn ssstkscdkt htcppcpape llggpsvflf ppkpkdtlmi srtpevtcvv vdvshedpev kfnwyvdgve vhnaktkpre eqynstyrvv svltvlhqdw lngkeykckv snkalpapie ktiskakgqp repqvytlpp srdeltknqv sltclvkgfy psdiavewes ngqpennykt tppvldsdgs fflyskltvd ksrwqqgnvf scsvmhealh nhytqkslsl spgk

Gln22 predicted

Lyophilized

The predicted molecular weight of Recombinant Mouse MAdCAM-1 is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 85-95 kDa.

63

The protein has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Briskin, MJ. et al. (1995) J Immunol. 155: 2477
2. Jackson, D. et al. (1997) Immunol Res. 16: 299
3. Ringler, DJ. et al. (1997) Am J Pathol. 151: 97